Trade between the two countries is flourishing as the two sides seek warmer and more-lucrative ties.
Uzbekistani officials are offering to help build Afghanistan and calling for the international community to aid their war-stricken neighbour.
By developing trade and reducing poverty, Tajikistan is eliminating grounds for radicalisation, say observers.
Citizens of both countries are enjoying easier border crossings, while businesses plan ambitious joint ventures.
For the first time in years Kyrgyz farmers and business owners crossed over the border on a officially sanctioned visit to sell and buy goods in Tajikistan.
For the first time in 25 years of independence, Tajikistan hosted a trade fair of Uzbekistan's exports.
The government May 5 will discuss allowing any Uzbekistani citizen to buy real estate in Tashkent and to reside there legally.
Recently restored air travel links and joint business projects show the two countries' growing interests toward each other, observers say.
Officials are considering ideas such as establishing a duty-free zone and a tourism police force.
The main challenges the ten Economic Co-operation Organisation (ECO) countries face are extremism, terrorism and drug trafficking, officials say.