A UN investigation determined that Syria and Russia committed war crimes and possible crimes against humanity during the battle for Syria's opposition-held Idlib.
Presidents Mirziyoyev and Tokayev reached out to each other after the incident and discussed the importance of continuing close co-operation to overcome new challenges and common threats.
The threats come after IRGC Navy ships conducted aggressive maneuvers near US vessels last week.
The article asserted that Kazakhstan is historically Chinese and is a 'vassal of the Qing Dynasty'. Observers say it is unlikely Beijing was unaware of the article.
Mirziyoyev and his Afghan counterpart Ghani vowed to work together to stop the spread of COVID-19 and reaffirmed their commitment to establishing peace in Afghanistan.
The United States seeks a Central Asia free from 'malign actors' and empowered to pursue economic opportunities that will benefit all citizens in the region.
The US Secretary of State also emphasised that Central Asian be sovereign and independent, and push back against Russia and China's attempts at economic and military domination.
Unlimited flights between Kazakhstan and the United States, as well as many other advantages provided by the signed agreement, will promote tourism and trade.
The talks also covered the issues of extremism, radicalisation, drug trafficking and the peace process in Afghanistan.
Uzbekistan has long sought to stabilise its war-stricken neighbour.